Disruption to normal excitatory and inhibitory function within the medial prefrontal cortex in people with chronic pain

ConclusionThe dysregulation of glutamatergic and GABAergic neurotransmitter systems supports a model of disinhibition of chronic pain, which may play a key role in both the experience of persistent pain and its associated affective disturbances.

Source: European Journal of Pain - July 10, 2021 Category: Anesthesiology Authors: David Kang, Negin Hesam ‐Shariati, James H. McAuley, Monzurul Alam, Zina Trost, Carolyn D. Rae, Sylvia M. Gustin Tags: ORIGINAL ARTICLE Source Type: research