The ethics of split liver transplantation: Analyzing case studies to make the right decision

(Carnegie Mellon University) In a new article, researchers address some of the ethical decisions that go into decisions to split a liver and provide a model to help hospitals make SLT decisions.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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We describe a successfully diagnosed and treated CHL-PTLD stage IV pediatric patient, 8 years after liver transplantation. The patient was treated with standard CHL (Children’s Cancer Group 5942 group 3) chemotherapy, rituximab and reduction of immunosuppressant. The patient remains in complete remission after 3 years with stable graft function. To our best knowledge, this is the first pediatric case report of a successfully treated stage IV CHL-PTLD after a liver transplant.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
Hepatitis-associated aplastic anemia (HAAA) has been reported in 23% to 33% of patients who received orthotopic liver transplantation (LT) for acute liver disease of unknown origin (nonviral hepatitis). In this situation, hematopoietic stem cell transplantation (HSCT) might be a curative option. Here the authors report on 6 patients who received HSCT after LT for nonviral HAAA hepatitis. The outcomes were interpreted in the context of recently reported immune suppressive therapy (IST) outcomes in 8 patients with HAAA and to HSCT outcomes in patients with HAAA who recovered from hepatitis without undergoing LT. All patients...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
Conclusions: In this cohort, there seems to be an association between SCD and AILD; SC in this population was severe. Physicians should be aware of this and evaluate patients with SCD and elevated liver enzymes for AILD.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Original Articles Source Type: research
For patients with hepatocelluar carcinoma (HCC), liver transplant from a live donor improves survival and frees up organs from deceased donors for other patients on the long waiting list.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
CONCLUSION: In the modern era there is a considerable increase in HDD patients in the Valencian Community. There was a center effect in the development of HDD programs, most of the patients depended on few healthcare centers. The patients were older and had greater comorbidity in the modern era, despite this without affecting the technical and overall survival of the HDD.PMID:34556353 | DOI:10.1016/j.nefro.2021.08.003
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Authors: Source Type: research
(Natural News) In this episode of the Health Ranger Report, Health Ranger Mike Adams speaks with Jonathan Landsman, the founder of the Fatty Liver docu class, to discuss the importance of a healthy liver. Right off the bat, the pair talk about keeping the liver healthy, and how transplants are not always necessary for those who have...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Ann Hepatol. 2021 Sep 20:100539. doi: 10.1016/j.aohep.2021.100539. Online ahead of print.ABSTRACTThe algorithms can have several purposes in the clinical practice. There are different scales to causality imputation in DILI (Drug Induced Liver Injury), but the applicability and validity of these for the HILI (Herb Induced Liver Injury) evaluation is questionable for some scales. The purpose of the study was to determine the clinical and demographic profile of the patients with HILI, and the main algorithmic scales used in its causality assessment. The methodology was a systematic review of articles in English, Spanish, or P...
Source: Annals of Hepatology - Category: Gastroenterology Authors: Source Type: research
World J Hepatol. 2021 Aug 27;13(8):904-915. doi: 10.4254/wjh.v13.i8.904.ABSTRACTThe multi-organ failure syndrome associated with acute and acute-on-chronic liver failure (ACLF) is thought to be mediated by overwhelming systemic inflammation triggered by both microbial and non-microbial factors. Therapeutic plasma exchange (TPE) has been proven to be an efficacious therapy in autoimmune conditions and altered immunity, with more recent data supporting its use in the management of liver failure. Few therapies have been shown to improve survival in critically ill patients with liver failure who are not expected to survive unt...
Source: World Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
World J Hepatol. 2021 Aug 27;13(8):830-839. doi: 10.4254/wjh.v13.i8.830.ABSTRACTSince the adoption of the model for end-stage liver disease (MELD) score for organ allocation in 2002, numerous changes to the system of liver allocation and distribution have been made with the goal of decreasing waitlist mortality and minimizing geographic variability in median MELD score at time of transplant without worsening post-transplant outcomes. These changes include the creation and adoption of the MELD-Na score for allocation, Regional Share 15, Regional Share for Status 1, Regional Share 35/National Share 15, and, most recently, th...
Source: World Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Clin Mol Hepatol. 2021 Sep 23. doi: 10.3350/cmh.2021.0276. Online ahead of print.NO ABSTRACTPMID:34551504 | DOI:10.3350/cmh.2021.0276
Source: Clinical and molecular hepatology - Category: Gastroenterology Authors: Source Type: research
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