Association between neutrophil –lymphocyte ratio on arterial stiffness in type-2 diabetes mellitus patients: a part of DiORS Study

This study is part of the Diabetic Ocular Renal Surabaya Study (DiORS Study). Participants were measured for their NLR count by dividing absolute neutrophil count with absolute lymphocyte count in peripheral blood and measuring of arterial stiffness with baPWV. The statistical analysis in use included independent t-test, Mann –Whitney test, Pearson correlation test, or Spearman correlation test. The results of the statistical analysis were significant ifp   1.65). The mean of baPWV was 15.19 ± 2.72 m/s with a range of 10.20–23.30 m/s, and 75.0% of them saw an increased arterial stiffness (baPWV >  13.5 m/s). Association analysis between NLR count and arterial stiffness shows significant results (r = 0.235;p 
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research

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Nature Reviews Endocrinology, Published online: 26 October 2021; doi:10.1038/s41574-021-00575-1This Review summarizes adaptive immune cell dysregulation in obesity and type 2 diabetes mellitus (T2DM). Under-appreciated comorbidities of obesity and T2DM (oral cavity inflammation, neuroinflammation and dysbiosis) are considered, and previous clinical trials of anti-inflammatory therapies for T2DM are discussed.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research
This study aimed to evaluate the association between obesity, evaluated by fat mass index (FMI) with the risk of microvascular diseases in patients with type 2 diabetes mellitus (T2DM) and compare the magnitude of associations of FMI, body mass index (BMI), and waist circumference (WC) with the risk of microvascular diseases. We performed a post-hoc analysis of the Action to Control Cardiovascular Risk in Diabetes study. The primary microvascular outcomes of the present study included chronic kidney disease (CKD) progression, retinopathy, and neuropathy. Cox proportional-hazards models were performed to evaluate the associ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conclusion: Chromosomal microdeletions in 16 p11.2, including the SH2B1 gene, in children are associated with severe, early-onset obesity and comorbidities associated with insulin resistance. Early genetic testing in suspicious patients and early screening for comorbidities is recommended.
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
Clin Chim Acta. 2021 Oct 19:S0009-8981(21)00362-4. doi: 10.1016/j.cca.2021.10.018. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is an umbrella term for a range of conditions caused by a build-up of fat in the liver. It is usually seen in people who are overweight or obese. Increasingly common around the world, this disease is the most common chronic liver disease in the United States, affecting about a quarter of the population. Recently, the designation of NAFLD as 'metabolic dysfunction-associated fatty liver disease' (MAFLD) has been a subject of current debate. In this context, 'insulin resis...
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Source Type: research
ConclusionsThe frequency ofGCK-diabetes is approximately 2% in non-obese Maltese adults with diabetes or prediabetes. This study broadens the mutational spectrum ofGCK and highlights clinical features that could be useful in discriminatingGCK-DM from type 2 DM or prediabetes. It reinforces the need for increased molecular testing in young adults with diabetes having a suspected monogenic aetiology.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
ConclusionThe beneficial effects of antioxidative vitamins (C, D, E) or their combination with other agents on lipid profile varied based on their dosage, intake duration, and the health status of the individuals.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
CONCLUSION: We found that environmental factors may influence the gene-disease relationship. Reciprocally, the genetic factors may alter the environment-disease relationship. To precisely conclude that the two factors act synergistically to lead to T2DM, more attention has to be paid to the combined influence of the genetic variants and environmental factors on T2DM occurrence instead of studying the influence of the factors separately.PMID:34669123 | DOI:10.1007/s11033-021-06837-5
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Source Type: research
CONCLUSIONS: Better surveillance of pubertal girls with obesity is crucial and can be achieved using additional information provided by an OGTT, since they appear to be at a higher risk for beta-cell exhaustion. During the OGTT, not only are the baseline and 2-hour glucose and insulin measurements useful for predicting future metabolic risks and development of T2DM in children and adolescents with obesity, but additional time measurements may also be helpful.PMID:34661258 | DOI:10.26355/eurrev_202110_26876
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Authors: Source Type: research
Endocr J. 2021 Oct 15. doi: 10.1507/endocrj.EJ21-0381. Online ahead of print.ABSTRACTHigh mobility group box 1 (HMGB1) is an alarmin that may link to obesity and type 2 diabetes mellitus (T2DM). The present study analyzed the correlation between HMGB1/ Toll-like receptor 4 (TLR4) and certain biochemical parameters in obese (OB) diabetic patients. 40 normal glucose tolerant subjects (NGT) and 40 patients with newly diagnosed T2DM were enrolled. All patients were further divided into non-obese NGT (NGT-NOB), obese NGT (NGT-OB), non-obese T2DM (T2DM-NOB) and obese T2DM (T2DM-OB) groups according to body mass index (BMI).The l...
Source: Endocrine Journal - Category: Endocrinology Authors: Source Type: research
CONCLUSIONS: Better surveillance of pubertal girls with obesity is crucial and can be achieved using additional information provided by an OGTT, since they appear to be at a higher risk for beta-cell exhaustion. During the OGTT, not only are the baseline and 2-hour glucose and insulin measurements useful for predicting future metabolic risks and development of T2DM in children and adolescents with obesity, but additional time measurements may also be helpful.PMID:34661258 | DOI:10.26355/eurrev_202110_26876
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Authors: Source Type: research
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