The Impact of Uric Acid and Hyperuricemia on Cardiovascular and Renal Systems

The description of gout dates back almost 5000  years, and scientific interest in uric acid increased when it was found to be involved in the pathogenesis of gout. Since then, many basic and clinical studies have assessed the implications of uric acid for the oxidative system, inflammation, and cardiovascular and renal outcomes. Uric acid–low ering therapy failed to improve clinical hard outcomes in asymptomatic hyperuricemia, and it is retained in symptomatic hyperuricemia. Dietary and lifestyle modifications are critical to manage hyperuricemia. More studies are warranted to investigate the role of uric acid–lowering drugs on cardiov ascular outcomes.
Source: Cardiology Clinics - Category: Cardiology Authors: Source Type: research