In vitro efficacy of antibiotics against different Borrelia isolates

Acta Microbiol Immunol Hung. 2021 Jul 6. doi: 10.1556/030.2021.01441. Online ahead of print.ABSTRACTIn the present study, the effectiveness of six antimicrobial agents have been tested against 24 borrelia strains isolated from Ixodes ricinus ticks (11 Borrelia lusitaniae, eight Borrelia afzelii, three Borrelia garinii and two Borrelia valaisiana) and one B. lusitaniae strain isolated from human skin. The minimum inhibitory concentration range of antimicrobial agents was as follows: amoxicillin, 0.125-2 mg/L; doxycycline, 0.125-1 mg/L, ceftriaxone, 0.016-0.063 mg/L; cefuroxime, 0.063-1 mg/L; azithromycin, 0.0017-0.11 mg/L; amikacin 32-512 mg/L. Potentially pathogenic B. lusitaniae and B. valaisiana species were more susceptible to amoxicillin and azithromycin than pathogenic B. afzelii and B. garinii (P
Source: Acta Microbiologica et Immunologica Hungarica - Category: Microbiology Authors: Source Type: research

Related Links:

The high polymorphism of Major Histocompatibility Complex (MHC) genes is generally considered to be a result of pathogen-mediated balancing selection. Such selection may operate in the form of heterozygote advantage, and/or through specific MHC allele–pathogen interactions. Specific MHC allele–pathogen interactions may promote polymorphism via negative frequency-dependent selection (NFDS), or selection that varies in time and/or space because of variability in the composition of the pathogen community (fluctuating selection; FS). In addition, divergent allele advantage (DAA) may act on top of these forms of bal...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Immunobiology. 2021 Jul 13;226(5):152091. doi: 10.1016/j.imbio.2021.152091. Online ahead of print.ABSTRACTThe spike protein of coronavirus is key target for drug development and other pharmacological interventions. In current study, we performed an integrative approach to predict antigenic sites in SARS-CoV-2 spike receptor binding domain and found nine potential antigenic sites. The predicted antigenic sites were then assessed for possible molecular similarity with other known antigens in different organisms. Out of nine sites, seven sites showed molecular similarity with 54 antigenic determinants found in twelve pathogen...
Source: Immunobiology - Category: Allergy & Immunology Authors: Source Type: research
J Vector Borne Dis. 2020 Apr-Jun;57(2):189-192. doi: 10.4103/0972-9062.310870.NO ABSTRACTPMID:34290166 | DOI:10.4103/0972-9062.310870
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Authors: Source Type: research
Emerg Infect Dis. 2021 Aug;27(8):2017-2024. doi: 10.3201/eid2708.204763.ABSTRACTLyme disease, or Lyme borreliosis, is the most common tickborne disease in the United States and Europe. In both locations, Ixodes species ticks transmit the Borrelia burgdorferi sensu lato bacteria species responsible for causing the infection. The diversity of Borrelia species that cause human infection is greater in Europe; the 2 B. burgdorferi s.l. species collectively responsible for most infections in Europe, B. afzelii and B. garinii, are not found in the United States, where most infections are caused by B. burgdorferi sensu stricto. St...
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
In conclusion, seasonality is an important environmental factor that influences immune responses, in addition to specific genetic and nongenetic host factors, and this may well explain the seasonal variation in the incidence and severity of immune-mediated diseases.PMID:34261668 | DOI:10.4049/jimmunol.2000133
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research
Availability of highly parallelized immunoassays has renewed interest in the discovery of serology biomarkers for infectious diseases. Protein and peptide microarrays now provide a rapid, high-throughput platform for immunological testing and validation of potential antigens and B-cell epitopes. However, there is still a need for tools to prioritize and select relevant probes when designing these arrays. In this work we describe a computational method called APRANK (Antigenic Protein and Peptide Ranker) which integrates multiple molecular features to prioritize potentially antigenic proteins and peptides in a given pathoge...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
More News: Allergy & Immunology | Amoxicillin | Azithromycin | Borrelia | Ceftriaxone | Cefuroxime | Doxycycline | Lyme Disease | Microbiology | Rocephin | Serbia Health | Skin | Study | Zithromax