Istradefylline, an adenosine A2a receptor antagonist, ameliorates neutrophilic airway inflammation and psoriasis in mice.

ConclusionThese results indicate that adenosine-mediated IL-17A production plays a role in neutrophilic inflammation models, and moreover, istradefylline, ARL67156, and AMP-CP are effective in animal models of neutrophilic inflammation. Some clinical relevancies in COVID-19 are discussed. (248 words)

Source: Clinical and Experimental Neuroimmunology - July 6, 2021 Category: Neurology Authors: Mieko Tokano, Masaaki Kawano, Rie Takagi, Sho Matsushita Tags: ORIGINAL ARTICLE Source Type: research