Forkhead box P1 (Foxp1) in osteoblasts regulates bone mass accrual and adipose tissue energy metabolism

In this study, we observed that bone also acts as an important endocrine source for AdipoQ, and its capacity in osteoblasts is controlled by the forkhead box P1 (FOXP1) transcriptional factor. Deletion of theFoxp1 gene in osteoblasts led to augmentation of AdipoQ levels accompanied by fueled energy expenditure in adipose tissues. In contrast, overexpression ofFoxp1 in bones impaired AdipoQ secretion and restrained energy consumption. Chromatin immunoprecipitation sequencing (ChIP-seq) analysis revealed thatAdipoQ expression, which increases as a function of bone age, is directly controlled by FOXP1. Our results indicate that bones, especially aged bones, provide an important source of a set of endocrine factors, including AdipoQ, that control body metabolism. © 2021 American Society for Bone and Mineral Research (ASBMR).

Source: Journal of Bone and Mineral Research - July 8, 2021 Category: Orthopaedics Authors: Wei Zhang, Pei Liu, Shifeng Ling, Fuhua Wang, Shaojiao Wang, Tienan Chen, Rujiang Zhou, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Jiqiu Wang, Haley O. Tucker, Xizhi Guo Tags: Original Article Source Type: research