Prognostic implications of tumor infiltrating lymphocytes for recurrence in epithelial ovarian cancer

Clin Exp Immunol. 2021 Jun 30. doi: 10.1111/cei.13639. Online ahead of print.ABSTRACTThe recurrence of patients with epithelial ovarian cancer (EOC) is largely attributed to tumour cells escaping from the surveillance of immune cells. However, to date there are a lack of studies that have systematically evaluated the associations between the infiltration fraction of immune cells and the recurrence risk of EOC. Based on the microRNA expression profiles of 441 EOC patients, we constructed a microRNA-based panel with recurrence prediction potential using nonnegative matrix factorization consensus clustering. Then, we evaluated the association between recurrence risk and infiltration proportions across ten immune cell types by CIBERSORT and a multivariable Cox regression model. As a result, we identified a 72 microRNA-based panel that could stratify patients into high and low risk of recurrence. The infiltration of plasma cells and M1 macrophages was consistently significantly associated with the risk of recurrence in patients with EOC. Plasma cells were significantly associated with a decreased risk of relapse (HR 0.58, p = 0.006), while M1 macrophages were associated with an increased risk of relapse (HR 1.59, p = 0.003). Therefore, the 72 microRNA-based panel, M1 macrophages and plasma cells may hold potential to serve as recurrence predictors of EOC patients in clinical practice.PMID:34195995 | DOI:10.1111/cei.13639
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Source Type: research