Untargeted lipidomics uncovers lipid signatures distinguishing severe versus moderate forms of acutely decompensated cirrhosis
Acutely decompensated of cirrhosis is a heterogeneous clinical entity associated with moderate mortality. In some patients, this condition develops quickly into a more often deadly acute-on-chronic liver failure (ACLF), in which other organs such as the kidneys or brain fail. The aim of this study was to characterize the blood lipidome in a large series of patients with cirrhosis and identify specific signatures associated with acute decompensation and ACLF development.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Joan Cl ària, Anna Curto, Richard Moreau, Benoit Colsch, Cristina López-Vicario, Juan José Lozano, Ferran Aguilar, Florence A. Castelli, François Fenaille, Christophe Junot, Ingrid Zhang, Maria Vinaixa, Oscar Yanes, Paolo Caraceni, Jonel Trebicka, Jav Source Type: research