On the assessment of arterial compliance from carotid pressure waveform

Am J Physiol Heart Circ Physiol. 2021 Jul 2. doi: 10.1152/ajpheart.00241.2021. Online ahead of print.ABSTRACTIn a progressively aging population, it is of utmost importance to develop reliable, noninvasive, and cost-effective tools to estimate biomarkers which can be indicative of cardiovascular risk. Various pathophysiological conditions are associated to changes in the total arterial compliance (CT), and thus its estimation via an accurate and simple method is valuable.Direct noninvasive measurement of CT is not feasible in the clinical practice. Previous methods exist for indirect estimation of CT, which, however, require noninvasive, yet complex and expensive, recordings of the central pressure and flow. Here, we introduce a novel, noninvasive method for estimating CT from a single carotid waveform measurement using regression analysis. Features were extracted from the carotid wave and are combined with demographic data. A prediction pipeline is adopted for estimating CT using, firstly, a feature-based regression analysis and, secondly, the raw carotid pulse wave. The proposed methodology was appraised using the large human cohort (n=2256) of the Asklepios study. Accurate estimates of CT were yielded for both prediction schemes; namely, r=0.83 and normalized-RMSE=9.58% for the feature-based model, and r=0.83 and normalized-RMSE=9.67% for the model which used the raw signal. The major advantage of this method pertains to the simplification of the technique offering easily ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Source Type: research