Antimicrobial and antioxidant activities of secondary metabolites from endophytic fungus < em > Botryosphaeria fabicerciana < /em > (MGN23-3) associated to < em > Morus nigra < /em > L

This study was to evaluate the biological activity of the extract of Botryosphaeria fabicerciana isolated from leaves of Morus nigra. The volatile compounds from the crude extract were analysed by GC-MS which demonstrate that mellein and β-orcinaldehyde were are the major compounds. The best minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extract was observed against Gram-positive bacteria, with a MIC of 15.6 μg/mL towards B. cereus and MIC of 62.5 μg/mL towards S. aureus and B. subtilis. MBC values of 31.25 μg/mL, 62.5 μg/mL, and 250 μg/mL were observed towards B. cereus, B. subtilis, and S. aureus, respectively. The cytotoxicity analyses showed CC50 of 115 μg/mL. The crude extract showed antioxidant activity by the DPPH, ABTS, and FRAP assays. Therefore, the extract of the endophytic fungus presented biotechnological potential as an antibacterial and antioxidant agent.PMID:34227409 | DOI:10.1080/14786419.2021.1947272

Source: Natural Product Research - July 6, 2021 Category: Biochemistry Authors: Angela Aparecida da Silva Julio Cesar Polonio Aline Maria Bulla Andressa Domingos Polli Juliana Cristina Castro Lilian Capelari Soares Verci Alves de Oliveira-Junior Veronica Elisa Pimenta Vicentini Arildo Jos é Braz de Oliveira Jos é Eduardo Gonçalves Source Type: research