24-NorUrsodeoxycholic acid reshapes immunometabolism in CD8+ T-cells and alleviates hepatic inflammation
24-NorUrsodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid for immune-mediated cholestatic liver diseases, such as primary sclerosing cholangitis (PSC) where dysregulated T-cells including CD8+ T-cells contribute to hepatobiliary immunopathology. We hypothesized that NorUDCA may directly modulate CD8+ T-cell function thus contributing to its therapeutic efficacy.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Ci Zhu, Nicole Boucheron, Andr é C. Müller, Peter Májek, Thierry Claudel, Emina Halilbasic, Hatoon Baazim, Alexander Lercher, Csilla Viczenczova, Daniela Hainberger, Teresa Preglej, Lisa Sandner, Marlis Alteneder, Alexandra F. Gülich, Matarr Khan, Pat Source Type: research