24-NorUrsodeoxycholic acid reshapes immunometabolism in CD8+ T-cells and alleviates hepatic inflammation

24-NorUrsodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid for immune-mediated cholestatic liver diseases, such as primary sclerosing cholangitis (PSC) where dysregulated T-cells including CD8+ T-cells contribute to hepatobiliary immunopathology. We hypothesized that NorUDCA may directly modulate CD8+ T-cell function thus contributing to its therapeutic efficacy.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research