T cells and monocyte-derived myeloid cells mediate immunotherapy-related hepatitis in a mouse model
Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events (irAEs) which are more severe when ICIs are used in combination. We aim to use a mouse model to elucidate the immune related molecular mechanisms of hepatitis, one of the common ICI irAEs.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Heather P. Llewellyn, Seda Arat, Jingjin Gao, Ji Wen, Shuhua Xia, Dalia Kalabat, Elias Oziolor, Richard Virgen-Slane, Timothy Affolter, Changhua Ji Source Type: research