Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus

CONCLUSION: Our study is the first to demonstrate that low intrinsic aerobic fitness that is associated with obesity and poor metabolic health is also linked with reduced hippocampal structural plasticity at a young age. Our results also suggest that inflammation of the brain could be one factor mediating the link between obesity and poor cognitive performance.PMID:34224822 | DOI:10.1016/j.bbi.2021.06.017

Source: Brain, Behavior, and Immunity - July 5, 2021 Category: Neurology Authors: Elina M äkinen Sanna Lensu Markus Honkanen Paavo Laitinen Jan Wikgren Lauren G Koch Steven L Britton Heikki Kainulainen Satu Pekkala Miriam S Nokia Source Type: research