Eculizumab exposure in children and young adults: indications, practice patterns, and outcomes —a Pediatric Nephrology Research Consortium study

ConclusionsThis multi-center retrospective cohort analysis indicates that a significant number of children and young adults are being exposed to C5 blockade for off-label indications. Dosing schedules were highly variable, limiting outcome conclusions. Attributable adverse events appeared to be low. Cohort mortality (6.6%) was not insignificant. Prospective studies in homogenous disease cohorts are needed to support the role of C5 blockade in kidney outcomes.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research