APOL1 in an ethnically diverse pediatric population with nephrotic syndrome: implications in focal segmental glomerulosclerosis and other diagnoses

ConclusionsNovel discoveries include a substantial prevalence of HRG among patients self-reported White, worse kidney outcomes in HRGversus LRG children in the FSGS subgroup, and a trend of higher CKD progression risk associated with a single risk variant in the SRNS cohort. These findings suggestAPOL1-associated NS extends beyond patients self-reported non-White, the HRG effect is independent of FSGS, and a single risk variant may have a detrimental impact in children with NS.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research