Elevated Mood States in Patients With Parkinson's Disease Treated With Deep Brain Stimulation: Diagnosis and Management Strategies

CONCLUSIONS: Preoperative DBS evaluations should include a thorough assessment of psychiatric risk factors. The term "stimulation-induced elevated mood states" is proposed to describe episodes of elevated, expansive, or irritable mood and psychomotor agitation that occur during or shortly after DBS programming changes and may be associated with increased goal-directed activity, impulsivity, grandiosity, pressured speech, flight of ideas, or decreased need for sleep and may persist beyond stimulation adjustments. This clinical phenomenon should be considered for inclusion in the bipolar disorder category in future DSM revisions, allowing for increased recognition and appropriate management.PMID:34213980 | DOI:10.1176/appi.neuropsych.20080205
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Authors: Source Type: research

Related Links:

We reported DEGs with a nominal p-value of 0.8. The network construction was created using blockwiseModules function for consideration of computer efficiency. The module detection criteria were as follows: minimum module size of 50, deepsplit of 4, and merge threshold of 0.25. The merged modules were then summarized with module eigengene (ME) correlations>0.75. MEs were defined by their first principal component and were labeled with different colors as module names in the Results section. After the modules were generated, we conducted different enrichment analysis to explore the functional interpretation of genes withi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Okun (2012).New England Journal of Medicine.Deep brain stimulation (DBS) of the subthalamic nucleus inParkinson's disease (PD) has been highly successful in controlling the motor symptoms of this disorder, which include tremor, slowed movement (akinesia), and muscle stiffness or rigidity. The figure above shows the electrode implantation procedure for PD, where a stimulating electrode is placed in either thesubthalamic nucleus, (STN), a tiny collection of neurons within the basal ganglia circuit, or in the internal segment of theglobus pallidus, another structure in the basal ganglia (Okun, 2012). DBS of the STN is more co...
Source: The Neurocritic - Category: Neuroscience Authors: Source Type: blogs
More News: Bipolar | Brain | Deep Brain Stimulation | Depression | Mania | Neurology | Parkinson's Disease | Psychiatry | Sleep Disorders | Sleep Medicine