Transcriptional and metabolic regulation of EHEC and Citrobacter rodentium pathogenesis

Curr Opin Microbiol. 2021 Jul 2;63:70-75. doi: 10.1016/j.mib.2021.06.002. Online ahead of print.ABSTRACTEnterohaemorrhagic Escherichia coli (EHEC) is a gastrointestinal pathogen that colonizes the colonic epithelium of humans and ruminants using a Type Three Secretion System (T3SS). This system is indispensable for disease and is regulated in response to a plethora of host and microbiota derived signals. The murine pathogen, Citrobacter rodentium, has become an instrumental tool in studying EHEC infection mechanisms in vivo, given its natural ability to infect mice and reliance on the same colonisation machinery. Here, we provide a review of the most recent advancements in EHEC infection biology, focusing on transcriptional regulation of the T3SS in response to physiologically relevant signals and how colonisation impacts on the metabolic micro-environment of the host niche. We pay particular attention to studies that have employed the C. rodentium model for elucidation of such mechanisms in vivo.PMID:34224961 | DOI:10.1016/j.mib.2021.06.002
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Source Type: research