Polyploidy control in hepatic health and disease

A balanced increase in DNA-content (ploidy) is observed in some human cell types, including bone-resorbing osteoclasts, platelet-producing megakaryocytes, cardiomyocytes or hepatocytes. The impact of increased ploidy in hepatocytes for normal physiology and diverse liver pathologies is still poorly understood. Recent findings suggest swift genetic adaptation to hepatotoxic stress and the protection from malignant transformation as beneficial effects. Here, we discuss the molecular mechanisms regulating hepatocyte polyploidization in its implication for different liver diseases and hepatocellular carcinoma (HCC).
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Review Source Type: research