Analyzing the impact of ATF3 in tumorigenesis and immune cell infiltration of ovarian tumor: a bioinformatics study

AbstractATF3 is an essential transcription activator in regulating cancer-related genetic expression. To identify the role ofATF3 in ovarian tumor, we investigated the correlation betweenATF3 expression and the clinicopathological properties using multiple database. The cBioPortal and GEPIA database displayed the clinical information of ovarian patients harboring or without harboringATF3 mutation. Furthermore, we assessed the relationship between survival andATF3 expression level using Kaplan –Meier plotter, which reveals that the ovarian patients with higher expression ofATF3 suffered the worse overall survival and progression-free survival. The differentially expressed genes were analyzed using gene ontology, protein –protein interaction network, and gene set enrichment analysis to identify the hub gene and critical pathways, significantly affecting the tumorigenesis of ovarian tumor. Finally, we assessed the correlation betweenATF3 and immune cell infiltration using Tumor Immunoassay Resource (TIMER) database. The results demonstrated that higher expression has a positive correlation with macrophage infiltration, expression for M1- and M2-type macrophages. Our study suggests thatATF3 can regulate the cell cycle and heme-related oxidative phosphorylation process, and it may be a critical factor to regulate the macrophage cell to be infiltrated into ovarian cancer.ATF3 can be used as a biomarker for diagnosis and therapy of ovarian tumor.
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research