July 2021

App Helps Screen for Autism Spectrum Disorder Step It Up! : Get Active for Your Health Disruptive Leg Movement? : Managing Restless Legs Syndrome Protect Yourself From Lyme Disease Noisy Planet
Source: NIH News in Health - Category: Consumer Health News Source Type: news

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Molecular Psychiatry, Published online: 02 August 2021; doi:10.1038/s41380-021-01239-2Pre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism
Source: Molecular Psychiatry - Category: Psychiatry Authors: Source Type: research
bib Tiziana Pascucci Guanidinoacetate methyltransferase deficiency (GAMT-D) is one of three cerebral creatine (Cr) deficiency syndromes due to pathogenic variants in the GAMT gene (19p13.3). GAMT-D is characterized by the accumulation of guanidinoacetic acid (GAA) and the depletion of Cr, which result in severe global developmental delay (and intellectual disability), movement disorder, and epilepsy. The GAMT knockout (KO) mouse model presents biochemical alterations in bodily fluids, the brain, and muscles, including increased GAA and decreased Cr and creatinine (Crn) levels, which are similar to those observed in h...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
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Source: World Journal of Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
AbstractEarly diagnosis and treatment for autism spectrum disorder (ASD) pose challenges. The current diagnostic approach for ASD is mainly clinical assessment of patient behaviors. Biomarkers-based identification of ASD would be useful for pediatricians. Currently, there is no specific treatment for ASD, and evidence for the efficacy of alternative treatments remains inconclusive. The prevalence of ASD is increasing, and it is becoming more urgent to find the pathogenesis of such disorder. Metabolomic studies have been used to deeply investigate the alteration of metabolic pathways, including those associated with ASD. Me...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
Nature Reviews Neurology, Published online: 02 August 2021; doi:10.1038/s41582-021-00530-8The maternal immune activation (MIA) hypothesis proposes that inflammatory perturbations in utero can affect fetal neurodevelopment. This Review examines the emerging human evidence for an association between MIA and childhood neurodevelopmental disorders, including autism spectrum disorder, attention-deficit/hyperactivity disorder and Tourette syndrome.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
Dr. Auwaerter has consulted for DiaSorin, Adaptive Biotherapeutics and Pfizer; has done research sponsored by MicroB-Plex; has been an expert witness in malpractice cases involving Lyme disease; and is an unpaid board member of the American Lyme Disease Foundation. Dr. Kobayashi has no disclosures. Dr. Wormser reports receiving research grants from the Institute for Systems Biology and Pfizer, Inc. He has been an expert witness in malpractice cases involving Lyme disease; and is an unpaid board member of the non-profit American Lyme Disease Foundation.
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
AbstractIntroductionThe amygdala subnuclei regulate emotional processing and are widely implicated in social cognitive impairments often seen in children with autism spectrum disorder (ASD). Dysregulated amygdala development has been reported in young children with ASD; less is known about amygdala maturation in later adolescence, a sensitive window for social skill development.MethodsThe macrostructural development of the amygdala subnuclei was assessed at two time points in a longitudinal magnetic resonance imaging (MRI) study of adolescents with ASD (n = 23) and typically-developing adolescents (n = 15) . In adolescents...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSIONS: The cost of RLS therapy is a significant part of patient expenditure. Nevertheless, RLS may at times remain so troublesome for patients that they are willing to spend more on therapy to eliminate symptoms.PMID:34333733 | DOI:10.1007/s11325-021-02440-x
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Source Type: research
Retail worker Romilly, who is autistic, wants to create a comfortable space for other autistic people to shop in.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Retail worker Romilly, who is autistic, wants to create a comfortable space for other autistic people to shop in.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
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