Development of a photoacoustic microscopy technique to assess peritubular capillary function and oxygen metabolism in the mouse kidney
Microcirculatory changes and oxidative stress have long been associated with acute kidney injury. Despite substantial progress made by two-photon microscopy of microvascular responses to acute kidney injury in rodent models, little is known about the underlying changes in blood oxygen delivery and tissue oxygen metabolism. To fill this gap, we developed a label-free kidney imaging technique based on photoacoustic microscopy, which enables simultaneous quantification of hemoglobin concentration, oxygen saturation of hemoglobin, and blood flow in peritubular capillaries in vivo.
Source: Kidney International - Category: Urology & Nephrology Authors: Naidi Sun, Shuqiu Zheng, Diane L. Rosin, Nabin Poudel, Junlan Yao, Heather Perry, Rui Cao, Mark D. Okusa, Song Hu Tags: technical notes Source Type: research
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