Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRI

Technology Bundle IDE-240-1998-0 Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRIApplicationsResearch MaterialsDiagnosticsLinked IDTAB-925Lead InventorsRobert Balaban (NHLBI)Co-InventorsAnthony Aletras ()Kathleen Ward ()ICsNHLBIAvailable for licensing is an MRI image improving system wherein at least one contrast agent is administered to a subject in amounts effective to perform chemical exchange dependent saturation transfer (CEDST) MRI analysis.Examples of contrast agents suitable for administration as exogenous contrast agents include at least one functional group bearing a proton capable of chemical exchange. Examples of these functional groups include, without limitation, amides, amines, and carboxyl, hydroxyl, and sulfhydryl groups.The contrast agent can be administered as a solid, as a dispersion or solution, such as an aqueous composition, as a mixture of two or more agents, etc. The contrast agent may also be in the form of a polymer.One feature of the present invention involved identifying contrast agents, which contain the functional groups having the appropriate proton exchange and chemical shift properties at physiological pH and temperature to function effectively for performing CEDST MRI analyses in vivo. A number of different contrast agents can be used to practice the present method for performing CEDST MRI analyses in vivo can be selected from the group consisting of: sugars, including oligosaccharides and polysacch...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research