Oral Transglutaminase 2 Inhibitor Beneficial in Celiac Disease

THURSDAY, July 1, 2021 -- For patients with celiac disease, treatment with a selective oral transglutaminase 2 inhibitor (ZED1227) attenuates gluten-induced duodenal mucosal damage, according to a study published in the July 1 issue of the New...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Conditions:   Celiac Disease;   Diet, Gluten-Free;   Exercise;   Resistance Training;   Quality of Life;   Body Composition Interventions:   Behavioral: Gluten-free nutrition plan + exercise group;   Behavioral: Gluten-free nutrition plan group;   Behavioral: Active Comparator: Celiac controls group Sponsor:   University of Alicante Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Wondering how people are doing volumes in BR pancreas when using conventional chemorads. The recently published Preopanc trial based volumes strictly off of gross disease, albeit using a different dose schema. On the other hand, we've historically treated a large volume with ENI from above the celiac down to L2 and into the porta, including the para-aortic, portal venous, celiac, and SMA in the case of head tumors. Based strictly on tolerability, I suspect more people complete the more... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
Understand the challenges of utilizing a food frequency questionnaire to assess nutrient intake in those following a gluten-free diet.
Source: Journal of the American Dietetic Association - Category: Nutrition Authors: Tags: Late-breaking Research Abstracts Source Type: research
Condition:   Celiac Disease Intervention:   Other: urine sample taken during consultations Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Anti-phospholipid antibodies cannot be considered responsible for hypercoagulability and thrombotic events in COVID-19 patients. In COVID-19 patients, livedo reticularis and acrocyanosis do not appear to be cutaneous manifestations of APS.PMID:34541915 | DOI:10.1177/20587384211042115
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Authors: Source Type: research
Am J Clin Pathol. 2021 Sep 20:aqab104. doi: 10.1093/ajcp/aqab104. Online ahead of print.ABSTRACTOBJECTIVES: Forgoing biopsy for the diagnosis of celiac disease in children with tissue transglutaminase immunoglobulin A (tTG-IgA) levels greater than or equal to 10 times the upper limit of normal (≥10×ULN) has been advocated by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition.METHODS: Our retrospective study tested the specificity and positive predictive value (PPV) of the BioPlex 2200 assay (Bio-Rad Laboratories) in diagnosing celiac disease at the ≥10×ULN tTG-IgA threshold, whi...
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Source Type: research
J Clin Res Pediatr Endocrinol. 2021 Aug 18. doi: 10.4274/jcrpe.galenos.2021.2021.0139. Online ahead of print.ABSTRACTIt is well-known that in children with type 1 diabetes (T1D), the frequency of celiac disease (CD) is increased due to unclear mechanisms including autoimmune injury as well as shared genetic predisposition. Although histopathologic examination is gold standard, avoiding unnecessary endoscopy is crucial. Therefore, from the perspective of the clinicians and patients' families, the diagnosis of celiac disease remains challenging. With these in mind, a joint working group (Type 1 Diabetes and Celiac Disease Jo...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research
CONCLUSIONS: Anti-phospholipid antibodies cannot be considered responsible for hypercoagulability and thrombotic events in COVID-19 patients. In COVID-19 patients, livedo reticularis and acrocyanosis do not appear to be cutaneous manifestations of APS.PMID:34541915 | DOI:10.1177/20587384211042115
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Authors: Source Type: research
J Clin Res Pediatr Endocrinol. 2021 Aug 18. doi: 10.4274/jcrpe.galenos.2021.2021.0139. Online ahead of print.ABSTRACTIt is well-known that in children with type 1 diabetes (T1D), the frequency of celiac disease (CD) is increased due to unclear mechanisms including autoimmune injury as well as shared genetic predisposition. Although histopathologic examination is gold standard, avoiding unnecessary endoscopy is crucial. Therefore, from the perspective of the clinicians and patients' families, the diagnosis of celiac disease remains challenging. With these in mind, a joint working group (Type 1 Diabetes and Celiac Disease Jo...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research
In conclusion, this survey raises the awareness of the discordances and serves as a starting point towards further standardization of the pancreatoduodenectomy grossing and reporting protocols.
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
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