Anti-RANKL monoclonal antibody and bortezomib prevent mechanical unloading-induced bone loss

ConclusionsWe demonstrated for the first time that anti-RANKL antibody and Bzb had a positive effect on preventing mechanical unloading-induced bone loss. This finding puts forward the potential use of anti-RANKL and Bzb on bone loss therapies or prophylaxis of astronauts in spaceflight.

http://link.springer.com/10.1007/s00774-021-01246-x

Source: Journal of Bone and Mineral Metabolism - July 1, 2021 Category: Orthopaedics Source Type: research