Borrelia afzelii infection in the rodent host has dramatic effects on the bacterial microbiome of Ixodes ricinus ticks

Appl Environ Microbiol. 2021 Jun 30:AEM0064121. doi: 10.1128/AEM.00641-21. Online ahead of print.ABSTRACTThe microbiome of blood-sucking arthropods can shape their competence to acquire and maintain infections with vector-borne pathogens. We used a controlled study to investigate the interactions between Borrelia afzelii, which causes Lyme disease in Europe, and the bacterial microbiome of Ixodes ricinus, its primary tick vector. We applied a surface sterilization treatment to I. ricinus eggs to produce dysbiosed tick larvae that had a much lower bacterial abundance and a changed bacterial microbiome compared to the control larvae. Dysbiosed and control larvae were fed on B. afzelii-infected mice and uninfected control mice and the engorged larvae were left to molt into nymphs, which were tested for B. afzelii infection and their bacterial microbiome by 16S rRNA amplicon sequencing. Surprisingly, larval dysbiosis had no effect on the vector competence of I. ricinus for B. afzelii, as the nymphal infection prevalence and the nymphal spirochete load were the same between the dysbiosed group and the control group. The strong effect of egg surface sterilization on the tick bacterial microbiome largely disappeared once the larvae molted into nymphs. The most important determinant of the bacterial microbiome of I. ricinus nymphs was the B. afzelii infection status of the mouse on which the nymphs had fed as larvae. Nymphs that had taken their larval blood meal from an infected mous...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Source Type: research

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Radiologia (Engl Ed). 2021 Sep-Oct;63(5):425-435. doi: 10.1016/j.rxeng.2021.07.002.ABSTRACTInfections of the central nervous system caused by atypical bacteria are becoming more common. Borrelia burgdorferi and Rickettsia conorii are microorganisms transmitted by ticks; infection with these bacteria result in a wide spectrum of manifestations on imaging. In areas where these tick-borne microorganisms are endemic, including Spain, these infections must be included in the differential diagnosis of patients with a variety of systemic and neurologic symptoms. The clinical presentation of these infections is nonspecific, and CT...
Source: Radiologia - Category: Radiology Authors: Source Type: research
FINDINGSA UCLA study suggests that many physicians may not have the knowledge or training to properly recognize how Lyme disease appears on the skin of Black patients. The disease, caused by the tick-borne Borrelia bacterium, generally begins with a bull ’s-eye–shaped rash on the skin, along with fever, headache, chills and muscle pain; if not diagnosed promptly and treated with antibiotics, it can lead to more severe and long-lasting symptoms.UCLA ’s Dr. Dan Ly found that approximately 1 in 3 Black patients who were newly diagnosed with Lyme disease already had related neurological complications such as ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Identifying the mechanisms driving disease risk is challenging for multi-host pathogens, such as Borrelia burgdorferi sensu lato (s.l.), the tick-borne bacteria causing Lyme disease. Deer are tick reproduction ho...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Radiologia. 2021 Aug 25:S0033-8338(21)00122-3. doi: 10.1016/j.rx.2021.07.003. Online ahead of print.ABSTRACTInfections of the central nervous system caused by atypical bacteria are becoming more common. Borrelia burgdorferi and Rickettsia conorii are microorganisms transmitted by ticks; infection with these bacteria result in a wide spectrum of manifestations on imaging. In areas where these tick-borne microorganisms are endemic, including Spain, these infections must be included in the differential diagnosis of patients with a variety of systemic and neurologic symptoms. The clinical presentation of these infections is no...
Source: Radiologia - Category: Radiology Authors: Source Type: research
Emerg Infect Dis. 2021 Aug;27(8):2017-2024. doi: 10.3201/eid2708.204763.ABSTRACTLyme disease, or Lyme borreliosis, is the most common tickborne disease in the United States and Europe. In both locations, Ixodes species ticks transmit the Borrelia burgdorferi sensu lato bacteria species responsible for causing the infection. The diversity of Borrelia species that cause human infection is greater in Europe; the 2 B. burgdorferi s.l. species collectively responsible for most infections in Europe, B. afzelii and B. garinii, are not found in the United States, where most infections are caused by B. burgdorferi sensu stricto. St...
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Publication date: Available online 12 July 2021Source: Ticks and Tick-borne DiseasesAuthor(s): Taylor J. Van Gundy, Amy J. Ullmann, Kevin S. Brandt, Robert D. Gilmore
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
We present a case of a patient who suffered from serious complications associated with the treatment of “chronic Lyme disease.” Lyme disease, a tick-borne infection caused by Borrelia burgdorferi, is characterized by dermatological, rheumatological, neurological, and/or cardiac manifestations responsive to antimicrobial therapy. “chronic Lyme disease”, by contrast, is a term used to describe a constellation of subjective symptoms, often without clinical or serological evidence of previous Lyme disease.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Letter to the editor Source Type: research
Appl Environ Microbiol. 2021 Jun 30:AEM0064121. doi: 10.1128/AEM.00641-21. Online ahead of print.ABSTRACTThe microbiome of blood-sucking arthropods can shape their competence to acquire and maintain infections with vector-borne pathogens. We used a controlled study to investigate the interactions between Borrelia afzelii, which causes Lyme disease in Europe, and the bacterial microbiome of Ixodes ricinus, its primary tick vector. We applied a surface sterilization treatment to I. ricinus eggs to produce dysbiosed tick larvae that had a much lower bacterial abundance and a changed bacterial microbiome compared to the contro...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Source Type: research
At my animal hospital in upstate New York, an epicenter of the U.S. tick epidemic, my dog Fawn lets out a whimper as the veterinarian injects her with her annual Lyme disease shot. I roll my eyes. She doesn’t know how good she has it. The injection means that if a tick bites her (and in rural New York, a tick always does), the creepy crawly will feast on dog blood that’s been supercharged with a Lyme bacteria-killing substance, and Lyme disease won’t be transmitted to Fawn. I wish I could be shot up with that superpower. Currently, there is no human vaccine for Lyme disease—even though more than two...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Disease feature Source Type: news
Publication date: Available online 10 June 2021Source: Ticks and Tick-borne DiseasesAuthor(s): Katherine A. Wolcott, Gabriele Margos, Volker Fingerle, Noémie S. Becker
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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