Discordance of PD-L1 status between primary and metastatic breast cancer: a systematic review and meta-analysis

The phenomenon of receptor conversion during progression from early to metastatic breast cancer (BC) is well-described [1 –5]. This observation underscores the need to obtain metastatic biopsies, since they lead to changes in management in approximately 15-20% of patients [4–6]. As a result of the potential clinical validity and utility, obtaining a metastatic biopsy should be considered in line with contemporary g uidelines [7,8].

Source: Cancer Treatment Reviews - June 30, 2021 Category: Cancer & Oncology Authors: Caroline Boman, Ioannis Zerdes, Kira M årtensson, Jonas Bergh, Theodoros Foukakis, Antonios Valachis, Alexios Matikas Source Type: research