Impulse control disorders are associated with lower ventral striatum dopamine D3 receptor availability in Parkinson's disease: a [11C]-PHNO PET study

Reduced postsynaptic D3 dopaminergic receptor availability has been reported in the ventral striatum of pathological gamblers without Parkinson ’s disease (PD) and in patients with PD and impulse control disorders (ICD). However, a direct relationship between ventral striatum D3 dopaminergic receptors and the severity of ICD in PD patients has not yet been proven using a validated tool for ICD in PD, such as the Questionnaire for Impulsiv e-Compulsive Disorders in Parkinson's disease-Rating Scale (QUIP-RS).
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research