Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma

Intratumor molecular heterogeneity is a key feature of tumorigenesis and is linked to treatment failure and patient prognosis. Here, we aimed to determine what drives tumor cell evolution by performing single-cell transcriptomic analysis.

Source: Journal of Hepatology - June 30, 2021 Category: Gastroenterology Authors: Lichun Ma, Limin Wang, Subreen A. Khatib, Ching-Wen Chang, Sophia Heinrich, Dana A. Dominguez, Marshonna Forgues, Juli án Candia, Maria O. Hernandez, Michael Kelly, Yongmei Zhao, Bao Tran, Jonathan M. Hernandez, Jeremy L. Davis, David E. Kleiner, Bradfor Source Type: research