Cross-sectional and longitudinal interaction effects of physical activity and APOE- ε4 on white matter integrity in older adults: the MAPT study

Brain white matter (WM) deterioration is a well-known marker of cerebral aging [1] which can be assessed through diffusion tensor imaging (DTI), the most widely used technique for measuring the microstructural integrity of WM fiber tracts [2,3]. DTI metrics include fractional anisotropy (FA), as well as axial (AxD), radial (RD) and mean diffusivity (MD). FA and MD are overall indicators of WM tract integrity, with high FA and low MD values indicating high WM integrity [4] . AxD and RD respectively reflect the diffusivity along and perpendicular to the main axis of the WM tracts [4].

Source: Maturitas - June 29, 2021 Category: Primary Care Authors: J érémy Raffin, Yves Rolland, Lingxiao He, Lisa Perus, Jean-François Mangin, Audrey Gabelle, Kelly Virecoulon Giudici, Bruno Vellas, Philipe de Souto Barreto, For the MAPT/DSA Group Source Type: research