Anaplastic lymphoma kinase (ALK) overexpression is associated with aggressive phenotypic characteristics of ovarian high-grade serous carcinoma

Deregulated full-length anaplastic lymphoma kinase (ALK) overexpression has been found in some primary solid tumors, but little is known about its role in ovarian high-grade serous carcinoma (HGSC). Here we focused on the functional roles of ALK in HGSC. Cytoplasmic ALK immunoreactivity without chromosomal rearrangement and gene mutations was significantly higher in HGSC as compared to non-HGSC type ovarian carcinomas, and was significantly associated with several unfavorable clinicopathological factors and poor prognosis.

Source: American Journal of Pathology - June 28, 2021 Category: Pathology Authors: Toshihide Matsumoto, Yusuke Oda, Yoshinori Hasegawa, Miki Hashimura, Yasuko Oguri, Hisako Inoue, Ako Yokoi, Masataka Tochimoto, Mayu Nakagawa, Zesong Jiang, Makoto Saegusa Source Type: research