Pharmacokinetics of meropenem during advanced organ support (ADVOS < sup > ® < /sup > ) and continuous renal replacement therapy

Int J Artif Organs. 2021 Jun 18:3913988211021101. doi: 10.1177/03913988211021101. Online ahead of print.ABSTRACTThe advanced organ support (ADVOS) system allows to eliminate water-soluble as well as protein-bound molecules. Despite its clinical features, to date nothing is known about the elimination of clinically relevant drugs such as antiinfectives. Therefore, we report a case treated with ADVOS, continuous renal replacement therapy (CRRT), and meropenem (1 g 8-hourly) for empiric sepsis therapy monitored by meropenem drug levels. ADVOS showed more efficient elimination of meropenem compared to CRRT which has to be considered when evaluating dosing regimens.PMID:34144656 | DOI:10.1177/03913988211021101
Source: The International Journal of Artificial Organs - Category: Transplant Surgery Authors: Source Type: research