Calories May Outweigh Nutrients in Diets for Fatty Liver Calories May Outweigh Nutrients in Diets for Fatty Liver

Calories may matter more than fat or carbohydrates in dieting to treat non-alcoholic fatty liver disease.Medscape Medical News
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Gastroenterology News Source Type: news

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AbstractBackground and aimsAcute-on-chronic liver failure (ACLF) is considered a main prognostic event in patients with chronic liver disease (CLD). We analyzed the 28-day and 90-day mortality in ACLF patients with or without underlying cirrhosis enrolled in the ACLF Research Consortium (AARC) database.MethodsA total of 1,621 patients were prospectively enrolled and 637 (39.3%) of these patients had cirrhosis. Baseline characteristics, complications and mortality were compared between patients with and without cirrhosis.ResultsAlcohol consumption was more common in cirrhosis than non-cirrhosis (66.4% vs. 44.2%,p 
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Trends Mol Med. 2021 Nov 20:S1471-4914(21)00277-X. doi: 10.1016/j.molmed.2021.10.005. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a metabolic disorder affecting over one quarter of the global population. Liver fat accumulation in NAFLD is promoted by increased de novo lipogenesis leading to the development of a proatherosclerotic lipid profile and atherosclerotic cardiovascular disease (CVD). The CVD component of NAFLD is the main determinant of patient outcome. The farnesoid X receptor (FXR) and the G protein bile acid-activated receptor 1 (GPBAR1) are bile acid-activated receptors that modu...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
In a mouse model of aging-related hepatic steatosis, 588 aging-related differentially expressed proteins (DEPs) were identified in the livers of old mice using liquid chromatography –mass spectrometry. Among them, AIMP2 was the most significantly upregulated protein. Aging induced the activation of O-GlcNAcylation and increased AIMP2 O-GlcNAcylation. The AIMP2 O-GlcNAcylation promoted PARP1 overactivation, thereby causing liver NAD+ deletion and hepatic steatosis. AbstractThe prevalence of non-alcoholic fatty liver disease (NAFLD) increases with aging. However, the mechanism of aging-related NAFLD remains unclear. He...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Research Article Source Type: research
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi-organ involvement. This entity has displaced viral hepatitis as the main cause of severe forms of hepatic diseases, although the onset and transition of MAFLD stages still remains unclear. Nevertheless, innate and adaptive immune responses seem to play an essential role in the establishment and further progression of this disease. The immune system is responsible of safeguard and preserves organs and systems function, and might be altered un...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The association of non-alcoholic fatty liver disease (NAFLD) with dietary factors is well established but not thoroughly investigated. This systematic review and meta-analysis synthesizes available evidence regarding the effect of nutrition on the presence and severity of NAFLD.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Conditions:   Non-Alcoholic Fatty Liver Disease;   Fatty Liver, Nonalcoholic;   Obesity Intervention:   Behavioral: Mindfulness Based Stress Reduction (MBSR) Sponsor:   Virginia Commonwealth University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: We identified a novel mechanism of post-transcriptional regulation of LDLR activity in humans and associations of genetic variants of RBM25 with LDL-cholesterol levels.PMID:34809444 | DOI:10.1161/CIRCRESAHA.120.318141
Source: Circulation Research - Category: Cardiology Authors: Source Type: research
Contributor : Alvarez MarcusSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death world-wide. The prevalence of non-alcoholic fatty liver disease (NAFLD) has been rising, along with an increase in NAFLD-related HCC. To investigate cell-type composition in NAFLD and HCC, we performed single-nucleus RNA-seq (snRNA-seq) of patients with fatty liver disease in order to transcriptionally characterize cell-types in an unbiased manner. Out data reveal a large amount of heterogeneity in hepatocyte populations, as wel...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
This study assesses the role of the PNPLA3 polymorphism for the development of LC and its complications by the findings of genetic examinations. Methods: Patients with LC caused by virus (n = 157), alcohol (n = 104), nonalcoholic fatty liver disease (NAFLD) (n = 106), or autoimmune disease (n = 33) and without LC (n = 128) were enrolled. LC were composed of the present and absent of complications, such as variceal bleeding, hepatic ascites, and/or hepatic encephalopathy. To assess the role of the PNPLA3 polymorphism, odds ratio (OR) for the rs738409 variant was calculated for the patients between (i) with LC and without LC...
Source: Digestive Diseases - Category: Gastroenterology Source Type: research
Biochem Biophys Res Commun. 2021 Nov 16;585:169-176. doi: 10.1016/j.bbrc.2021.11.038. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity, insulin resistance, and endoplasmic reticulum (ER) stress. Elevated circulating levels of the hepatokine leukocyte cell-derived chemotaxin-2 (LECT2) have also been noted in NAFLD; however, the mechanism underlying this association is unclear. To investigate a possible link between ER stress/unfolded protein response (UPR) signaling and LECT2 secretion, HepG2 cells were incubated with ER stress inducers with or without an ER stres...
Source: Cell Research - Category: Cytology Authors: Source Type: research
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