Study shows potential dangers of sweeteners

(Anglia Ruskin University) New research has discovered that common artificial sweeteners can cause previously healthy gut bacteria to become diseased and invade the gut wall, potentially leading to serious health issues. The study, published in the International Journal of Molecular Sciences, is the first to show the pathogenic effects of some of the most widely used artificial sweeteners - saccharin, sucralose, and aspartame - on two types of gut bacteria, E. coli (Escherichia coli) and E. faecalis (Enterococcus faecalis).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Colloids Surf B Biointerfaces. 2021 Sep 17;208:112097. doi: 10.1016/j.colsurfb.2021.112097. Online ahead of print.ABSTRACTThe negative electrical charge of Escherichia coli and Enterococcus faecalis bacteria is an indication that they can be affected by an electric field. To show that the movements of electrically charged bacteria can be controlled, impedance spectroscopy method was used on a porous silicon (PS) structure with 60 % porosity and 7-12 μm pore size. The main purpose of this study is to use the electric charge of these two bacterial species to bring bacteria closer to the sensors with the help of an electri...
Source: Colloids and Surfaces - Category: Biotechnology Authors: Source Type: research
Conclusion: The prevalence of UTI and MDR to commonly used antibiotics among diabetic patients is alarming, and thus, isolation of uropathogenic bacteria and antimicrobial susceptibility testing is crucial for the treatment of UTI in persons with diabetes.
Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
Parasitol Res. 2021 Sep 21. doi: 10.1007/s00436-021-07313-6. Online ahead of print.ABSTRACTAncylostoma ceylanicum is a common zoonotic nematode that inhabits the small intestine of humans, dogs, and cats. Saposin-like proteins (SLPs) have hemolytic and antibacterial activities and could be used as diagnostic or vaccine candidates. To explore the biological functions of Ancylostoma ceylanicum SLP (Ace-SLP-1), cDNA-encoding Ace-SLP-1 mature peptide was cloned into prokaryotic expression vector pET-28a and transformed into Escherichia coli BL21 (DE3) to induce expression. After incubation of canine red blood cell suspension w...
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSION: The study revealed an alarming rate of resistance to the commonly used antimicrobial agents used in treating HAIs. Also the relationship between AMR and some risk factors and thus taking steps towards controlling them have been shown.PMID:34540152 | PMC:PMC8408023 | DOI:10.18502/ijm.v13i2.5978
Source: Iranian Journal of Microbiology - Category: Microbiology Authors: Source Type: research
Amosova A novel family of [1,4]thiazino[2,3,4-ij]quinolin-4-ium derivatives was synthesized by annulation reactions of 8-quinolinesulfenyl chloride with unsaturated heteroatom and heterocyclic compounds. It was found that the reactions with 4-pentenoic and 5-hexenoic acids, allyl chloride and bromide, allyl cyanate and vinyl heterocyclic compounds (N-vinyl pyrrolidin-2-one and 1-vinylimidazole) proceeded in a regioselective mode but with the opposite regiochemistry. The reactions with vinyl heterocyclic compounds included electrophilic addition of the sulfur atom of 8-quinolinesulfenyl chloride to the β-carbon ato...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
The aim of this study was to explore the effect of short-chain inulin on cecal microbiota of high-fat diet-fed leptin knockout mice and the different influences of cecal microbiota on wild-type and leptin knockout mice. A total of 18 specific pathogen-free male C57BL/6J wild-type mice and 18 C57BL/6J leptin knockout mice (OB/OB mice) were selected. Mice were divided into six groups according to their genotype: wild-type mice have three groups, including the normal diet group (CT), 60% high-fat diet group (CH), and 60% high fat with 10% short-chain inulin group (CHI); OB/OB mice were also divided into three groups, includin...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Arch Microbiol. 2021 Aug 28. doi: 10.1007/s00203-021-02536-8. Online ahead of print.ABSTRACTIn the present study, metabolic characteristics, such as lactic acid, hydrogen peroxide, exopolysaccharide (EPS) production, and antimicrobial activities, of 17 Enterococcus faecium isolates from white cheese samples were assessed. In E. faecium isolates, the amount of lactic acid obtained between in MRS medium 0.61-1.22% and in skim milk 0.75-1.08%, and the amount of H2O2 was found between 0.57 and 3.17 µg mL-1. In MRS and skim milk, the amount of EPS production was 59-185 mg L-1, 155-255 mg L-1 for isolates, respectively. Th...
Source: Archives of Microbiology - Category: Microbiology Authors: Source Type: research
Altered gut microbiota and a damaged colon mucosal barrier have been implicated in the development of colon cancer. Astragalus mongholicus Bunge-Curcuma aromatica Salisb. (ACE) is a common herbal drug pair that widely used clinically to treat cancer. However, whether the anti-cancer effect of ACE is related to gut microbiota remains unclear yet. We standardized ACE and investigated the effects of ACE on tumour suppression and analyze the related mechanisms on gut microbiota in CT26 colon cancer-bearing mice in the present study. Firstly, four flavonoids (calycosin-7-glucoside, ononin, calycosin, formononetin) and three ast...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: A WISCA is a data-driven, clinically intuitive tool that can be used to compare empiric antibiotic regimens for paediatric sepsis using existing large datasets. The estimates can be further refined using more complex meta-analytical methods, and patient characteristics.PMID:34424116 | DOI:10.1080/14787210.2021.1967145
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Authors: Source Type: research
Necrotic enteritis (NE), an economically devastating disease of poultry caused by pathogenic Clostridium perfringens, is known to induce small intestinal lesions and dysbiosis. However, the intestinal microbes that are associated with NE severity are yet to be characterized. Here, we investigated the link between the ileal microbiota and disease severity in a chicken model of clinical NE using 16S rRNA gene sequencing. Our results indicated that richness and Shannon Index of the ileal microbiota were drastically reduced (p
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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