Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-14 amplification

In conclusion, our study demonstrated that SHMT2 contributes to tumorigenesis in FP RMS and that SHMT2 amplification predicts differential response to drugs targeting this metabolic pathway.PMID:34166228 | DOI:10.1172/JCI138022

Source: Clinical Lung Cancer - June 24, 2021 Category: Cancer & Oncology Authors: Thanh H Nguyen Prasantha L Vemu Gregory E Hoy Salah Boudjadi Bishwanath Chatterjee Jack F Shern Javed Khan Wenyue Sun Frederic G Barr Source Type: research