ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells

ConclusionsZEB1 could not only regulate EMT, but also inhibit GPX4 transcription by binding to the E-box motif. It was important to note that the ZEB1/GPX4 axis had a therapeutic effect on breast cancer metabolism.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research