Adenylyl Cyclase (AC) Mediates the Antidepressant-Like Effects of Tropisetron on a Mouse Model of Maternal Separation Stress

Depress Res Treat. 2021 Apr 22;2021:5586119. doi: 10.1155/2021/5586119. eCollection 2021.ABSTRACTThe adenylyl cyclase (AC) pathway is involved in the pathophysiology of depression. Finding new antidepressants with high medicinal properties and low side effects is warranted. Therefore, this study was designed to determine the antidepressant-like effect of tropisetron on a maternal separation (MS) model in mice, considering the possible role of AC. NMRI male mice were divided into eleven groups. The control group was treated with saline and MS groups were treated with saline, tropisetron (a 5-HT3 receptor antagonist) at doses of 1, 3, and 5 mg/kg; forskolin (an activator of AC) at doses of 5, 10, and 25 mg/kg; a subeffective dose of forskolin with a subeffective dose of tropisetron; and an effective dose of tropisetron plus an effective dose of NB001 (3 mg/kg) (an AC inhibitor). After treatment, animals were subjected to behavioral tests including the forced swimming test (FST), splash test, and open field test (OFT). We showed that MS caused depressive-like behaviors determined as an increase in the immobility time in the forced swimming test (FST) and decreased grooming time in the splash test. Our results showed that administration of tropisetron, as well as forskolin, mitigated the depressive-like behaviors in MS mice. We found that coadministration of a subeffective dose of tropisetron plus a subeffective dose of forskolin potentiated the antidepressant-like effect of trop...
Source: Depression Research and Treatment - Category: Psychiatry Authors: Source Type: research

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Condition:   Postpartum Depression Interventions:   Behavioral: Motherly app;   Behavioral: COMVC app Sponsor:   University of Sao Paulo Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractThe prevailing dominant discourse about motherhood in western societies reflects a set of interconnected beliefs referred to as intensive mothering ideology. Little is known about how intensive mothering ideology changes after childbirth, and the associations between intensive mothering ideology and maternal mental health. The current study aims to explore how intensive mothering ideology may evolve after childbirth in both primiparous and multiparous women, and whether any observed changes in this ideology impact maternal mental health. French women (n = 144) completed a set of study measures during late pregnancy...
Source: Sex Roles - Category: International Medicine & Public Health Source Type: research
Conclusions: The majority of neonates infected with LM were born preterm, raising the possibility that LM itself may have been responsible for preterm labor. All presented in the first 6 days of life and most presented with respiratory distress or depression. A high proportion had meningitis, and there was a high-mortality overall.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Maternal-Neonatal Reports Source Type: research
Swiss Med Wkly. 2021 Sep 17;151:w30009. doi: 10.4414/smw.2021.w30009. eCollection 2021 Sep 13.ABSTRACTInformation on the impact of the COVID-19 pandemic on pregnancy and breastfeeding experiences, as well as on perinatal mental health in Switzerland is limited. In Switzerland, there are few national studies and little information. Using an anonymous online survey accessible after the first wave of the outbreak in Switzerland, we have investigated how this pandemic affected pregnant and breastfeeding women. Among women who completed the survey, 69.0% (1050/1518) indicated the first wave of the pandemic affected their person...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Source Type: research
Addict Behav. 2021 Sep 3;124:107109. doi: 10.1016/j.addbeh.2021.107109. Online ahead of print.ABSTRACTSocial media use is on the rise among young adults (YA) and evidence suggests a positive association between social media addiction (SMA) and the psychological symptoms of depression and anxiety globally. However, the contribution of attachment and its transgenerational influence on YAs' SMA and psychological symptoms have not been widely explored. Thus, we examined how parental reports of attachment (anxiety and avoidance) can directly and through YAs' attachment predict YAs' SMA, depression and anxiety symptoms. A sample...
Source: Addictive Behaviors - Category: Addiction Authors: Source Type: research
Swiss Med Wkly. 2021 Sep 17;151:w30009. doi: 10.4414/smw.2021.w30009. eCollection 2021 Sep 13.ABSTRACTInformation on the impact of the COVID-19 pandemic on pregnancy and breastfeeding experiences, as well as on perinatal mental health in Switzerland is limited. In Switzerland, there are few national studies and little information. Using an anonymous online survey accessible after the first wave of the outbreak in Switzerland, we have investigated how this pandemic affected pregnant and breastfeeding women. Among women who completed the survey, 69.0% (1050/1518) indicated the first wave of the pandemic affected their person...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Source Type: research
AbstractNumerous studies report that some first-time parents experience a decline in relationship quality and an increase in conflict after the birth of a first baby. Inter-parental discord that is frequent, intense, and poorly resolved increases the likelihood of relationship breakdown and adversely impacts child development. We investigated the feasibility of a brief preventative couple-focused psychotherapeutic intervention in the perinatal period in a general population sample. Sixty couples expecting their first baby were recruited from the Royal Free Hospital, London. Thirty were randomly assigned to treatment (TMT, ...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
Conditions:   Cardiovascular Diseases;   Overweight;   Obesity;   Smoking;   Hypertension;   Cholesterol;   Diabetes Mellitus;   Prediabetic State;   Pregnancy;   Depression, Postpartum;   Depression;   Prevention;   Heart Disease Risk Factors Interventions:   Behavioral: Diabetes Prevention Program (DPP);   Behavioral: Reach Out, stay Strong, Essentials (ROSE);   Behavioral: Telephone Lifestyle Coaching Program (TLC) Sponsor:   VA Office of Research and Develo...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The large treatment gap for mental disorders in low- and middle-income countries (LMIC) necessitates task-sharing approaches in scaling up care for mental disorders. Previous work have shown that primary healt...
Source: International Journal of Mental Health Systems - Category: Psychiatry Authors: Tags: Study protocol Source Type: research
Daihai He The COVID-19 pandemic has hugely impacted global public health and economy. The COVID-19 has also shown potential impacts on maternal perinatal and neonatal outcomes. This systematic review aimed to summarize the evidence from existing systematic reviews about the effects of SARS-CoV-2 infections on maternal perinatal and neonatal outcomes. We searched PubMed, MEDLINE, Embase, and Web of Science in accordance with PRISMA guidelines, from 1 December 2019 to 7 July 2021, for published review studies that included case reports, primary studies, clinical practice guidelines, overviews, case-control studies, and...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
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