Upregulation of Nrf-2 attenuates oxidative stress-induced complement activation-associated endothelial injury and apoptosis in transplant-associated thrombotic microangiopathy.

Transplant-associated thrombotic microangiopathy (TA-TMA) is a recognized fatal complication after hematopoietic stem cell transplantation (HSCT). The pathological diagnosis is difficult due to the difficulty in obtaining biopsy samples in post-transplant patients. The TA-TMA incidence reported in previous studies ranges from 0 to 64%, while the mortality rate is as high as 60% to 75%.[1] TA-TMA patients' clinical manifestations include anemia, thrombocytopenia, elevated lactate dehydrogenase (LDH), increased schistocytes in the blood, severe hypertension, and proteinuria.

Source: Biology of Blood and Marrow Transplantation - June 22, 2021 Category: Hematology Authors: Rui Zhang, Jiaqian Qi, Meng Zhou, Tingting Pan, Ziyan Zhang, Yifang Yao, Haohao Han, Yue Han Source Type: research