Post-transplant Cyclophosphamide versus Thymoglobulin in HLA-Mismatched Unrelated Donor Transplant for AML and MDS

The ability to identify a fully HLA matched donor for patients requiring allogeneic stem cell transplant (alloSCT) has dramatically improved due mainly to the increase in the unrelated donor registries. As a result, up to 75% of Caucasian patients are able to find a suitable unrelated donor (1, 2). While participation of volunteers in the registry continues to increase, transplant access for other ethnic and racial minorities remains an area of critical need, often times, relying on less than fully matched donors.

Source: Biology of Blood and Marrow Transplantation - June 22, 2021 Category: Hematology Authors: Dipenkumar Modi, Kyle Kondrat, Seongho Kim, Abhinav Deol, Lois Ayash, Voravit Ratanatharathorn, Joseph P. Uberti Source Type: research