How pancreatic cancer cells dodge drug treatments

(Cold Spring Harbor Laboratory) Pancreatic cancer cells typically rely on a mutant version of the KRAS protein to proliferate. These cancer cells can also survive losing KRAS by activating alternative growth pathways. CSHL scientists discovered a new interaction between mutant KRAS and a protein complex called RSK1/NF1 that may be the source of this adaptive resistance.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news