Diabetes mellitus aggravates ranolazine-induced ECG changes in rats

ConclusionsIn summary, DM induction in animals resulted in CYP 3A2 inhibition and the prolongation of QT and QTc interval as well as bradycardia after ranolazine treatment.

Source: Journal of Interventional Cardiac Electrophysiology - June 21, 2021 Category: Cardiology Source Type: research