Chronic psychological stress attenuates the efficacy of anti-PD-L1 immunotherapy for bladder cancer in immunocompetent mice

Cancer Invest. 2021 Jun 19:1-28. doi: 10.1080/07357907.2021.1943746. Online ahead of print.ABSTRACTWe aimed to explore whether chronic psychological stress affected the efficacy of immune checkpoint inhibitors (ICIs) immunotherapy in bladder cancer. The chronic unpredictable mild stress (CUMS) process was applied during the administration of anti-PD-L1 for subcutaneous tumors in mice. Tumor regression was obviously shown in anti-PD-L1 therapy groups, while this effect was notably attenuated by CUMS. Additionally, increased infiltration of regulatory T cells, decreased amount of CD8+ lymphocytes, and reduced levels of tumor-associated cytokines in tumor sites were observed in mice treated with anti-PD-L1 under CUMS. Therefore, chronic psychological stress could weaken the potency of anti-PD-L1 immunotherapy for bladder cancer.PMID:34148483 | DOI:10.1080/07357907.2021.1943746
Source: Cancer Investigation - Category: Cancer & Oncology Authors: Source Type: research