The Sledgehammer in Precision Medicine: Dexamethasone and Immunotherapeutic Treatment of Glioma

Cancer Invest. 2021 Jun 21:1-18. doi: 10.1080/07357907.2021.1944178. Online ahead of print.ABSTRACTUnderstanding dexamethasone's effect on the immune microenvironment in glioma patients is of key importance. We performed a comprehensive literature review using the NCBI PubMed database for all articles meeting the following search criteria. ((dexamethasone[All Fields]) AND (glioma or glioblastoma)[Title/Abstract]) AND (immune or T cell or B cell or monocyte or neutrophil or macrophage). Forty-three manuscripts were deemed relevant to the topic at hand. Multiple clinical studies have linked dexamethasone use to decreased overall survival while preclinical studies in murine glioma models have demonstrated decreased tumor-infiltrating lymphocytes after dexamethasone administration.PMID:34151678 | DOI:10.1080/07357907.2021.1944178
Source: Cancer Investigation - Category: Cancer & Oncology Authors: Source Type: research