Distinct Molecular Subtypes of RSV Bronchiolitis Identified

Four biologically and clinically meaningful endotypes identified; asthma risk higher for endotype B compared with endotype A
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Infections, Pathology, Pediatrics, Pulmonology, Critical Care, Emergency Medicine, Journal, Source Type: news

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Allergol Immunopathol (Madr). 2021 Sep 1;49(5):32-41. doi: 10.15586/aei.v49i5.439. eCollection 2021.ABSTRACTBACKGROUND: We investigated the relationship between maternal smoking in pregnancy and health care problems in the offspring during the first year of life, particularly asthma.MATERIAL AND METHODS: A cohort of 648 consecutive infants born at term and alive at Hospital de Sagunto (Valencia, Spain) over one year period was followed for 12 months. Clinical data of the infants were prospectively collected from the database of ambulatory medical records (ABUCASIS) of the Valencia health system.RESULTS: Smoking during preg...
Source: Allergologia et Immunopathologia - Category: Allergy & Immunology Authors: Source Type: research
We present the case of a profoundly hypoxemic 16-year-old girl who presented in minimal distress, with oxyhemoglobin saturation of 63% on room air.
Source: Pediatric Emergency Care - Category: Emergency Medicine Tags: Illustrative Cases Source Type: research
Int J Environ Res Public Health. 2021 Aug 6;18(16):8347. doi: 10.3390/ijerph18168347.ABSTRACTRespiratory diseases contribute to high healthcare utilization rates among children. Although social inequalities play a major role in these conditions, little is known about the impact of geography as a determinant of health, particularly with regard to the difference between rural and urban centers. A regional geographic analysis was conducted using health repository data on singleton births between 2005 and 2010 in Alberta, Canada. Data were aggregated according to regional health sub-zones in the province and standardized preva...
Source: Rural Remote Health - Category: Rural Health Authors: Source Type: research
Tohoku J Exp Med. 2021;254(4):257-260. doi: 10.1620/tjem.254.257.ABSTRACTBronchiolitis obliterans is a chronic obstructive respiratory disease involving stenosis or occlusion of the bronchioles and smaller airways. The prognosis of bronchiolitis obliterans is poor, and the patient might require home oxygen therapy and/or lung transplantation. Bronchiolitis obliterans has various etiologies; in children, the most common causes are infections by respiratory pathogens like adenoviruses. In such cases, the condition is termed as postinfectious bronchiolitis obliterans. A 7-year-old girl was diagnosed with bronchial asthma at t...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Source Type: research
CONCLUSION: We confirmed that inhibition of NF-κB/IL-33/ST2 axis could attenuate acute bronchiolitis by RSV infected. Our findings not only demonstrate the potential role of IL-33 antibody in attenuating RSV-induced lung damage but also provide a new insight into better prevention of RSV-induced asthma by mediating NF-κB/IL-33/ST2 axis.PMID:34395633 | PMC:PMC8357524 | DOI:10.1155/2021/6625551
Source: Cell Research - Category: Cytology Authors: Source Type: research
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