The Impact of Depression on Outcomes in Patients with Heart Failure and Reduced Ejection Fraction Treated in the GUIDE-IT Trial

The syndrome of heart failure (HF) is quite often accompanied by a burden of comorbidities [1]. Among these, mental illness is often overlooked [2]. For example, studies show that depression is prevalent in up to 25% of all patients with HF and independently predicts adverse clinical outcomes [2]. It is suspected that effective and comprehensive care of HF requires a focus on confronting psychiatric comorbidities along with treatment of the cardiac disease. However, it remains unknown as to whether depression influences the medical treatment of HF or whether it interferes with the efficacy medical therapies.

Source: Journal of Cardiac Failure - June 21, 2021 Category: Cardiology Authors: Fouad Chouairi, Michael A. Fuery, Clancy W. Mullan, Cesar Caraballo, Sounok Sen, Christopher Maulion, Samuel T. Wilkinson, Toral Surti, Megan McCullough, P. Elliott Miller, Justin Pacor, Eric S Leifer, G. Michael Felker, Eric J. Velazquez, Mona Fiuzat, Ch Source Type: research