Centenarians as models of healthy aging: Example of REST

This study goes from human to animal models and revealed that REST acts as an epigenetic regulator of neuronal homeostasis, to control aging and longevity. The aim of this view point is to summarize recent literature describing genetic and epigenetic factors, as well as molecular pathways associated with centenarians and the biology of aging. We will pay particular attention to the impact of REST in centenarians and longevity.PMID:34139339 | DOI:10.1016/j.arr.2021.101392
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Source Type: research