Screening of LRP10 mutations in Parkinson ’s disease patients from Italy

Parkinson ’s disease (PD) belongs to a family of neurodegenerative diseases characterized by alpha-synuclein accumulation in neurons, whose etiopathogenesis remains largely uncovered. Recently, LRP10 has been associated with PD, Parkinson’s disease Dementia (PDD) and Dementia with Lewy Bodies (DLB) by lin kage analysis and positional cloning in an Italian family with late-onset PD. After the first characterization of a LRP10 pathogenic variant, other eight mutations have been detected in an international series of 660 probands with either a clinical or pathological diagnosis of PD, PDD or DLB.

Source: Parkinsonism and Related Disorders - June 18, 2021 Category: Neurology Authors: Arianna Manini, Letizia Straniero, Edoardo Monfrini, Marco Percetti, Maria Vizziello, Giulia Franco, Valeria Rimoldi, Anna Zecchinelli, Gianni Pezzoli, Stefania Corti, Giacomo Pietro Comi, Stefano Duga, Alessio Di Fonzo Tags: Short communication Source Type: research