Clinical features of advanced glaucoma with optic nerve head prelaminar schisis Prelaminar schisis in advanced glaucoma

The optic nerve head (ONH) is the posterior ocular structure that enables the exit of retinal ganglion cell axons, and consists of nerve fibers and glial and vascular tissue. The scleral portion of the ONH neural canal is spanned by connective tissue beams of the lamina cribrosa (LC), which enter the peripapillary scleral circumferential collagen fibers through the scleral canal wall. LC is supposedly the key site of pressure-related retinal ganglion cell axonal insult in glaucoma.1,2 Thus, glaucoma is characterized by a range of morphological changes in the ONH, including a narrowing of the neuroretinal rim, an enlargement of the excavation, and the loss of prelaminar neural tissue.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research