ONCOS-102 Vaccine Showing Impressive Results for Mesothelioma

The novel immunotherapy vaccine ONCOS-102 may become the answer for the large percentage of mesothelioma cancer patients who fail to respond to a recently approved checkpoint inhibitor combination of treatment. ONCOS-102, a genetically modified oncolytic adenovirus, showed an overall survival rate of between 21.9 and 25 months in a randomized phase II clinical trial when combined with standard chemotherapy in a first-line setting. By comparison, patients in the trial receiving only standard chemotherapy had a median survival of just 13.5 months. The vaccine is the lead product of Targovax, a small Scandinavian biotech company specializing in hard-to-treat cancers. “We now have the data for taking this further. We just have to be careful not blowing too many trumpets today and getting ahead of ourselves, but the results are impressive,” Dr. Magnus Jaderberg, chief medical officer at Targovax, told The Mesothelioma Center at Asbestos.com. “We’re excited about what we’ve seen.” New ONCOS-102 Study Likely  Targovax is expected to announce soon the launch of another study, potentially involving prominent mesothelioma specialty centers within the U.S. The study would pair ONCOS-102 with the immunotherapy combination of Opdivo and Yervoy, which was approved by the Food and Drug Administration in 2020 and the European Commission in 2021. A combination of Opdivo and Yervoy, known generically as nivolumab and ipilimumab, was the first systemic trea...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news