Recurrence score testing does not appear to benefit patients with Grade 1, progesterone receptor-positive breast cancers: an opportunity to eliminate overtreatment and decrease testing costs

Publication date: Available online 17 June 2021Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Udai S. Sibia, Thomas J. Sanders, Charles Mylander, Martin Rosman, Carol Tweed, Lorraine Tafra, Rubie S. Jackson
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research

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This article comprehensively reviews the endocrine resistance in hormone-positive BC from a molecular and genetic perspective, encompassing the updated treatment and developing direction. This review includes the mechanisms of hormone resistance, which vary from epigenetic changes, crosstalk between signaling networks, cell cycle aberrance, and even change in the tumor microenvironment (TME) or stem cell. These mechanisms may contribute to treatment resistance. Current targeted therapy for hormone-resistant tumors includes PI3K/AKT/mTOR and cdk4/6 inhibitors. Several relevant pathways, biomarkers, and predictor genes have ...
Source: Cell Research - Category: Cytology Authors: Source Type: research
This study provides insight on the use of a vasoactive agent to increase exposure of the blood-tumor barrier to chemotherapy with intention to improve glioma treatment efficacy.PMID:34521765 | DOI:10.1158/1541-7786.MCR-19-0995
Source: Cell Research - Category: Cytology Authors: Source Type: research
Contributors : Mohsen Fathi ; Robiya Joseph ; Jay R Adolacian ; Melisa Martinez-Paniagua ; Xingyue An ; Konrad Gabrusiewicz ; Sendurai A Mani ; Navin VaradarajanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusExpression profiling of mouse mammary cell lines, 67NR and 4T1, and glioblastoma cell lines, U87 and GSC20 stem cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
Mesenchymal stem cells are a progenitor of myofibroblasts and inflammatory carcinoma-associated fibroblasts. The present study identifies ELF3 as an essential transcription factor in the differentiation of this key pro-inflammatory stromal cell type. AbstractStromal cells in the tumor microenvironment regulate the immune landscape and tumor progression. Yet, the ontogeny and heterogeneity of reactive stromal cells within tumors is not well understood. Carcinoma-associated fibroblasts exhibiting an inflammatory phenotype (iCAFs) have been identified within multiple cancers, however mechanisms that lead to their recruitment ...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research
AbstractAcute myeloid leukemia (AML) relapse after allogeneic stem cell transplant (alloSCT) remains a major therapeutic challenge. While patients with longer remission after initial alloSCT are recommended to receive cell therapy (CT) such as 2ndalloSCT or donor lymphocyte infusion (DLI), survival for patients who relapse within 6  months of alloSCT has been dismal. We evaluated the outcomes of AML relapse after alloSCT to assess the impact of different treatments on long-term survival. One hundred and seventy-two patients with AML underwent alloSCT at the Penn State Cancer Institute from January 2014 to August 2019....
Source: Annals of Hematology - Category: Hematology Source Type: research
Accumulating evidence showed that cancer stem cells (CSCs) play significant roles in cancer initiation, resistance to therapy, recurrence and metastasis. Cancer stem cells possess the ability of self-renewal and can initiate tumor growth and avoid lethal factors through flexible metabolic reprogramming. Abnormal lipid metabolism has been reported to be involved in the cancer stemness and promote the development of cancer. Lipid metabolism includes lipid uptake, lipolysis, fatty acid oxidation, de novo lipogenesis, and lipid desaturation. Abnormal lipid metabolism leads to ferroptosis of CSCs. In this review, we comprehensi...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
The global coronavirus disease-2019 (COVID-19) pandemic has drastically disrupted many aspects of life and healthcare in unparalleled ways. For patients with cancer, it has impacted both treatment and recovery trajectories.1, 2 Patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT) are especially vulnerable to care changes imposed by the pandemic due to factors associated with HSCT, including the intensive treatment with a prolonged hospitalization, high burden of physical symptoms due to potential toxic side effects, and quality of life (QOL) challenges in recovery.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
i J. Unternaehrer High-grade serous carcinoma of the ovary is a deadly gynecological cancer with poor long-term survival. Dysregulation of microRNAs has been shown to contribute to the formation of cancer stem cells (CSCs), an important part of oncogenesis and tumor progression. The let-7 family of microRNAs has previously been shown to regulate stemness and has tumor suppressive actions in a variety of cancers, including ovarian. Here, we demonstrate tumor suppressor actions of let-7i: repression of cancer cell stemness, inhibition of migration and invasion, and promotion of apoptosis, features important for cancer pr...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Mesenchymal stem cells are a progenitor of myofibroblasts and inflammatory carcinoma-associated fibroblasts. The present study identifies ELF3 as an essential transcription factor in the differentiation of this key pro-inflammatory stromal cell type. AbstractStromal cells in the tumor microenvironment regulate the immune landscape and tumor progression. Yet, the ontogeny and heterogeneity of reactive stromal cells within tumors is not well understood. Carcinoma-associated fibroblasts exhibiting an inflammatory phenotype (iCAFs) have been identified within multiple cancers, however mechanisms that lead to their recruitment ...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research
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